By: Dr. Tabraiz Mohammed On June 15th 2016 Presented to the Advanced Practitioners Group

Tabraiz Mohammed, MD, Hematologist/Oncologist presents an excellent talk on the hemolytic anemia. Following topics are covered: Hemolysis Defective Hemoglobin Abnormal RBC Membrane Abnormal Enzymes Other pathologies

Dr. Tabraiz Mohammed discusses functional and quantitative disorders of the immune system. Immune reactions are also discussed.

This is the first part of the lab series for sickle cell diseases. Our kool beens have asked for this series for a long time.

In this recording of the FB live talk, we will discuss the following topics:

1. Red blood cells (RBCs)
2. RBCs function
   1. Oxygen transport via hemoglobin transport
   2. Carbon dioxide transport
   3. Buffering system for blood
3. RBCs lifetime
4. RBCs production sites
   1. Intrauterine life
      1. Liver
      2. Yolk sac
      3. Others
   2. Early life
      1. Long bone marrow (tibia, femur)
   3. Adult
      1. Membranous bones
         1. Vertebrae (primary manufacturers)
         2. Clavicle
         3. Sternum
         4. Ribs
         5. Iliac crests
5. Stages of the RBCs from formation to the destruction
   1. Totipotent STEM cells. (RBCs parent cells)
   2. Pluripotent Hematopoietic STEM cells
   3. Colony-forming unit spleen (CFU-S)
   4. Colony-forming unit blast cells (CFU-B)
   5. Colony-forming unit erythroblast (CFU-E)
   6. Pro-erythroblast
   7. Reticulocytes
   8. Erythrocytes (mature RBCs.)
6. Percentage of RBC life stages in the peripheral blood picture

Sickle cell labs. Part 2

Hemoglobin synthesis, function, and types.

Hb Gower 1

Hb A

Hb A2

Hb A1c

Hb F

Hb S

Hb C

Hb SS

Hb SC

Dr. William J. Murphy is a scientist with extensive experience with immune and cancer system interactions. Dr. Murphy has graciously offered to help us understand cancer immunology.
In the session today we will address as many of the following points as possible:
What is cancer? Basic tumor biology and misconceptions
Causes of cancer, changing demographics
Different cancer types and outcomes
Invasion and metastasis
Factors affecting incidence and progression (and outcome)
How to diagnose and treat (past and present)- factors affecting decisions
How do we study cancer in the research laboratory? Limitations
Immunology of cancer

Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento

How Dostarlimab Therapy Healed Colorectal Cancer

Link to the FDA channel: https://www.youtube.com/watch?v=DfdMsAqkneE

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Wednesday, Jun. 8 2022

Rectal Cancer Disappears After Experimental Use of Immunotherapy | Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/rectal-cancer-disappears-after-experimental-use-immunotherapy

PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2201445?articleTools=true

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors - Full Text View - ClinicalTrials.gov
https://clinicaltrials.gov/ct2/show/NCT04165772

Dostarlimab - Wikipedia
https://en.wikipedia.org/wiki/Dostarlimab

Programmed cell death protein 1 - Wikipedia
https://en.wikipedia.org/wiki/Programmed_cell_death_protein_1

Structures of PD-1 with its ligands: Sideways and dancing cheek to cheek - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492504/

Ectodomain - Wikipedia
https://en.wikipedia.org/wiki/Ectodomain

Treatment | Global Colon Cancer Association
https://www.globalcca.org/treatment

Colorectal Cancer Stages | Rectal Cancer Staging | Colon Cancer Staging
https://www.cancer.org/cancer/colon-rectal-cancer/detection-diagnosis-staging/staged.html

Dr. William Murphy Distinguished Prof., Vice Chair of Research for Dermatology and Internal Medicine departments discusses cancer immunotherapy. The following topics are discussed:
The new trends in this area and the mechanisms involved are being researched.
Cost, risk, success, and failure of various methods in this area.
Passive immunotherapy vs active immunotherapy is discussed.
CAR-T cell-related mechanics are discussed.

Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.

Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento

Dr. William Murphy Distinguished Prof., Vice Chair of Research for Dermatology and Internal Medicine departments discusses cancer immunotherapy. In this talk, he shares the progress with cancer immunotherapy, especially the CAR-T cells and how this technology represents a brave new frontier.

The following topics are discussed:
What are CAR-T cells?
Empowering the T cells and NK cells against cancers.
Engineering CAR-T cells.
Why T cells?
What cells are the sources of CARs?
How CAR are built?
Mechanism of action.