Why Relapses and Remissions in Chronic Inflammation?

Dr. William J. Murphy is a scientist with extensive experience with immune and the cancer system interactions. His knowledge of immunology is desperately needed for the chronic illnesses we are observing nowadays. I have three questions to run by Dr. Murphy:
Why do we get relapses and remissions in some chronic inflammatory conditions?
What is the way to get rid of the cells that are continuously making inflammatory molecules and antibodies?
For the vaccine trials what is the importance of mice test in older age mice?

Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general. 

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Monday, May. 23 2022

COVID Research - A Talk With Dr. William J. Murphy - YouTube
https://www.youtube.com/watch?v=UdmaZX3ftfY

Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento

A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694

Autoimmune Disease after Infection or Vaccine in Some (Article Review of Anti-idiotype Antibodies) - YouTube
https://www.youtube.com/watch?v=kE9UUX7NV5Q