Streptococcus Pyogenes - Clinical Foundations

Duration: 13:42

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mobeen@*.com

Sep 27 2018, 8:16 pm

Make sure that you grasp the concept of the M proteins and their role in preventing phagocytosis, and then body's response to opsonize them. Mobeen

We are sure that strep/sore throat is a routine presentation in your clinic. In the US only streptococci pyogenes cause millions of yearly visits to healthcare facilities. Streptococci cause disease by direct organ invasion, by their enzymes, and by releasing exotoxins. Understanding streptococci thoroughly and then wielding a great command over the management approach will help you continue to be amazing for your patients. In this two-part series, we will talk about the streptococcal foundations necessary to understand and manage the disease, and then various diseases and their management. Let's start with the first part here. Make sure that you have understood this before the second part about the diseases and their management.

In this lecture we will discuss the following topics:

Virulence potential
Habitat
- Throat
- Skin
Tests
- Erythrogenic/Pyogenic exotoxin
- Gram +
- PYR +
- RAD
- Catalase -
- Bacitracin sensitive
Antigenic components of the cell wall
- Hyaluronic acid
- C carbs
- M Proteins
- Exotoxins
Enzymes
- Streptolysin O
- Streptolysin S
- Streptokinase
- Hyaluronidase
- DNAse
- C5a Peptidase

These foundations will be used to look at the disease process, disease types, and the disease management in the next lecture.

* Acknowledge the high virulence of Streptococcus pyogenes.

* Appreciate the importance of key structures like the capsule.

* Identify the process of opsonization and its role in immune recognition and clearance of Streptococcus pyogenes.

* Recognize the roles of key enzymes such as Streptolysin O, Streptolysin S, and Streptokinase in tissue destruction and immune evasion.

* Understand the clinical manifestations linked with Streptococcus pyogenes infections, including scarlet fever and toxic shock syndrome.

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Faculty

In addition to the presenter, following authors may have helped with the content writing, review, or approval:

Dr. Mobeen Syed

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