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Shingles Vaccine Shingrix - Indications, Mechanism, and Side Effects

Duration: 22:26

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Nov 27 2023, 1:31 am

I'm 68 and just recovered from shingles. My doctor told me I should plan for the Shingrix shot in a year, and I asked why as having just recovered I thought I should now have some measure of natural immunity. He said natural immunity only lasts 1 year but the vaccine lasts for 10. How is that possible that any external derived immunity could last longer than natural immunity?



Jun 30 2023, 1:43 pm

That's what's frustating. My PCP says yes, my oncologist no, so I've gone with my oncologists recommendation at this point. I am 72. Thank you for such a quick response.

In this study Dr. Syed discusses the indications, mechanism of action, and side effects of the shingles vaccine Shingrix. There are two approved shingles vaccines, Zoostvax and Shingrix. However, Zoostvax has been discontinued since November 2020 in the USA. Shingrix is a sub-protein vaccine. It is made of glycoprotein E (gE) and an adjuvant AS01B. It trains the immune system to mount both the humoral and the cytotoxic responses. It is offered in 5 ml/dose for intramuscular administration, usually with a 2-6 months gap for the second dose. Let's review.


CDC Recommendations for Shingles Prevention | SHINGRIX (Zoster Vaccine Recombinant, Adjuvanted) for HCPs

New study reveals why the latest shingles vaccine is more than 90% effective | The Westmead Institute for Medical Research

Shingrix® (zoster vaccine recombinant, adjuvanted), developed by GlaxoSmithKline | College of Pharmacy - University of Minnesota

Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older | The Journal of Infectious Diseases | Oxford Academic

Varicella zoster vaccine (recombinant): Uses, Interactions, Mechanism of Action | DrugBank Online

A critical appraisal of ‘Shingrix’, a novel herpes zoster subunit vaccine (HZ/Su or GSK1437173A) for varicella zoster virus - PMC

Shingrix (herpes zoster subunit vaccine) for the Prevention of Shingles - Clinical Trials Arena

Package Insert - SHINGRIX

Shingles Vaccination: What Everyone Should Know | CDC

Zoster vaccine - Wikipedia

Varicella zoster virus - Wikipedia

Shingrix, INN-Herpes zoster vaccine (recombinant, adjuvanted)

Emerging concepts in the science of vaccine adjuvants | Nature Reviews Drug Discovery


Chickenpox (Varicella) for Healthcare Professionals | CDC

Frontiers | Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

* Recognize the characteristics of the varicella-zoster virus (VZV) and its association with shingles.

* Understand the epidemiology and clinical features of shingles, including its potential complications.

* Describe the Shingrix vaccine, its dosing schedule, and efficacy in preventing shingles.

* Explain the mechanism of action of Shingrix in inducing both humoral and cytotoxic immune responses.

* Identify common side effects and important safety information associated with the Shingrix vaccine.

* Know the indications for Shingrix vaccination and contraindications for its use.

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.


In addition to the presenter, following authors may have helped with the content writing, review, or approval:

  • Dr. Mobeen Syed

CME, CE, CEU and Other Credit Types:

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The DrBeen Corp is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA Credit Designation Statement
The DrBeen Corp designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Information

In accordance with the disclosure policies of DrBeen Corp and the ACCME (Accreditation Council for Continuing Medical Education), we are committed to upholding principles of balance, independence, objectivity, and scientific rigor in all of our Continuing Medical Education (CME) and Continuing Education (CE) activities. These policies include the careful management and mitigation of any relevant financial relationships with organizations that are not eligible.
All members of the Activity Planning Committee and presenters have disclosed their relevant financial relationships. The DrBeen Corp CE Committee has thoroughly reviewed these disclosures and determined that these relationships are not deemed inappropriate in the context of their respective presentations. Additionally, they are found to be consistent with the educational objectives and the integrity of the activity.

Faculty Disclosures
Dr. Mobeen Syed Author declares no conflict of interest.

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Dr. Mobeen Syed

Dr. Mobeen Syed

MD., MSc., MSc., BSc

Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.


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