Shingles Vaccine Shingrix - Indications, Mechanism, and Side Effects

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rhorocholyn@*.com

Nov 27 2023, 1:31 am

I'm 68 and just recovered from shingles. My doctor told me I should plan for the Shingrix shot in a year, and I asked why as having just recovered I thought I should now have some measure of natural immunity. He said natural immunity only lasts 1 year but the vaccine lasts for 10. How is that possible that any external derived immunity could last longer than natural immunity?

jlpick51@*.com

Jun 30 2023, 1:43 pm

That's what's frustating. My PCP says yes, my oncologist no, so I've gone with my oncologists recommendation at this point. I am 72. Thank you for such a quick response.

In this study Dr. Syed discusses the indications, mechanism of action, and side effects of the shingles vaccine Shingrix. There are two approved shingles vaccines, Zoostvax and Shingrix. However, Zoostvax has been discontinued since November 2020 in the USA. Shingrix is a sub-protein vaccine. It is made of glycoprotein E (gE) and an adjuvant AS01B. It trains the immune system to mount both the humoral and the cytotoxic responses. It is offered in 5 ml/dose for intramuscular administration, usually with a 2-6 months gap for the second dose. Let's review.

CDC Recommendations for Shingles Prevention | SHINGRIX (Zoster Vaccine Recombinant, Adjuvanted) for HCPs
https://shingrixhcp.com/cdc-recommendations/

New study reveals why the latest shingles vaccine is more than 90% effective | The Westmead Institute for Medical Research
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https://www.fda.gov/media/108597/download

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https://en.wikipedia.org/wiki/Varicella_zoster_virus

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* Recognize the characteristics of the varicella-zoster virus (VZV) and its association with shingles.

* Understand the epidemiology and clinical features of shingles, including its potential complications.

* Describe the Shingrix vaccine, its dosing schedule, and efficacy in preventing shingles.

* Explain the mechanism of action of Shingrix in inducing both humoral and cytotoxic immune responses.

* Identify common side effects and important safety information associated with the Shingrix vaccine.

* Know the indications for Shingrix vaccination and contraindications for its use.

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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In addition to the presenter, following authors may have helped with the content writing, review, or approval:

Dr. Mobeen Syed

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