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Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)

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Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)

We have been discussing the autoantibodies or anti-idiotype antibodies for a few days. A frequent question asked is "How does the immune system start attacking our own tissues while it was not doing so before the COVID infection, or a Spike protein vaccine?" Let's build our understanding of these mechanisms.

Page 350. Anergy and the role of tissue resident dendritic cells.
Page 350. B cell tolerance. A beautiful mechanism of B cell receptor editing.
Page 351. B cell deletion by an unknown mechanism.
Normal mechanism is B cell anergy in the presence of abundant antigen from all sides of the immature B cell.

Immunologic tolerance is defined as unresponsiveness to an antigen that is induced by exposure to that antigen. The term arose from the experimental observation that animals that had encountered an antigen under particular conditions would not respond to, that is, would tolerate, subsequent exposures to the same antigen.

Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 337). Elsevier Health Sciences. Kindle Edition. 

This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

In this talk we will go over the following topics:

1. What is self tolerance?

2. The mechanism of self-tolerance.

3. How does it breakdown in the presence of various external factors?

4. The mechanism of breakdown of self-tolerance due to a new microbe.

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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