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Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)

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Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus)

We have been discussing the autoantibodies or anti-idiotype antibodies for a few days. A frequent question asked is "How does the immune system start attacking our own tissues while it was not doing so before the COVID infection, or a Spike protein vaccine?" Let's build our understanding of these mechanisms.

Page 350. Anergy and the role of tissue resident dendritic cells.
Page 350. B cell tolerance. A beautiful mechanism of B cell receptor editing.
Page 351. B cell deletion by an unknown mechanism.
Normal mechanism is B cell anergy in the presence of abundant antigen from all sides of the immature B cell.

Immunologic tolerance is defined as unresponsiveness to an antigen that is induced by exposure to that antigen. The term arose from the experimental observation that animals that had encountered an antigen under particular conditions would not respond to, that is, would tolerate, subsequent exposures to the same antigen.

Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 337). Elsevier Health Sciences. Kindle Edition. 

This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

* Understand B and T cell formation and training in bone marrow and thymus.

* Recognize generative tissues presenting mainly self-antigens.

* Differentiate between central and peripheral immunologic tolerance.

* Comprehend positive and negative selection processes in thymus.

* Identify regulatory mechanisms like co-stimulation, anergy, and apoptosis in T cell regulation.

* Appreciate the crucial role of regulatory T cells in preventing autoimmunity.

* Recognize the concept of antigen mimicry.

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.


In addition to the presenter, following authors may have helped with the content writing, review, or approval:

  • Dr. Mobeen Syed

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The DrBeen Corp designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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All members of the Activity Planning Committee and presenters have disclosed their relevant financial relationships. The DrBeen Corp CE Committee has thoroughly reviewed these disclosures and determined that these relationships are not deemed inappropriate in the context of their respective presentations. Additionally, they are found to be consistent with the educational objectives and the integrity of the activity.

Faculty Disclosures
Dr. Mobeen Syed Author declares no conflict of interest.

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Dr. Mobeen Syed

Dr. Mobeen Syed

MD., MSc., MSc., BSc

Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.

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