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Restrictive Lung Diseases (Interstitial Pulmonary Fibrosis)

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Oct 27 2019, 12:12 pm

Is it respiratory alkalosis or acidosis. I am little confused



Feb 14 2020, 8:53 pm

Same im confused too. If there is increased CO2 conc in blood, it should result in respiratory acidosis, shouldnt it?



Sep 01 2020, 7:04 am

It surely acidosis

This video presents the introduction to the restrictive lung diseases We will discuss: 

  • Types 
    • Extrapulmonary restrictive lung diseases
      • Obesity
      • Scoliosis
    • Pulmonary parenchymal restrictive lung diseases
      • Idiopathic
      • Autoimmune
      • Granulomatous (Wagner's granulomatosis, Sarcoidosis)
      • Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
      • Other irritants
      • Chronic infections (Tuberculosis)
    • Neuromuscular restrictive lung diseases
      • Myasthenia gravis
      • Diaphragm issues
      • Polio

Cellular events/pathogenesis

  • Damaged Type I Pneumocytes
  • Hypertrophy of Type II Pneumocytes
  • Irritated epithelium
  • Irritated macrophages
  • Apoptosis of epithelium
  • Tissue damage leading to local inflammation and lung destruction/scaring.
  • Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
  • Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
  • Fibroblasts overactivity resulting in more extracellular matrix and hardening.
  • Epithelial-mesenchymal transformation.
  • Smooth muscle proliferation.
  • Respiratory interface thickening. Disrupted gaseous exchange.

Clinical Presentation

  • Dry hacking cough
  • Dyspnea
  • Hypoxia
  • Respiratory alkalosis
  • Late inspiratory crackles

Abnormal chest X-Ray

  • Reduced volume in chest X-Ray
  • Lower lobes show more involvement and the reason why.
  • Right heart failure/cor pulmonale 

Lung Function Changes

  • FEV1/FVC ratio increases > 80% (normal or above normal)


  • Anti-inflammatory (may not be very effective)
  • TGF Beta-blockers
  • Oxygen
  • Lung transplant

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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