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Restrictive Lung Diseases (Interstitial Pulmonary Fibrosis)

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1 Comments

abdullahkiller12@*.com

Oct 27 2019, 12:12 pm

Is it respiratory alkalosis or acidosis. I am little confused

hiba.hanif.razzak@*.com

Feb 14 2020, 8:53 pm

Same im confused too. If there is increased CO2 conc in blood, it should result in respiratory acidosis, shouldnt it?

mhc_zia38@*.com

Sep 01 2020, 7:04 am

It surely acidosis

This video presents the introduction to the restrictive lung diseases We will discuss:
Definition

Types
- Extrapulmonary restrictive lung diseases
  - Obesity
  - Scoliosis
- Pulmonary parenchymal restrictive lung diseases
  - Idiopathic
  - Autoimmune
  - Granulomatous (Wagner's granulomatosis, Sarcoidosis)
  - Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
  - Other irritants
  - Chronic infections (Tuberculosis)
- Neuromuscular restrictive lung diseases
  - Myasthenia gravis
  - Diaphragm issues
  - Polio

Cellular events/pathogenesis

Damaged Type I Pneumocytes
Hypertrophy of Type II Pneumocytes
Irritated epithelium
Irritated macrophages
Apoptosis of epithelium
Tissue damage leading to local inflammation and lung destruction/scaring.
Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
Fibroblasts overactivity resulting in more extracellular matrix and hardening.
Epithelial-mesenchymal transformation.
Smooth muscle proliferation.
Respiratory interface thickening. Disrupted gaseous exchange.

Clinical Presentation

Dry hacking cough
Dyspnea
Hypoxia
Respiratory alkalosis
Late inspiratory crackles

Abnormal chest X-Ray

Reduced volume in chest X-Ray
Lower lobes show more involvement and the reason why.
Right heart failure/cor pulmonale

Lung Function Changes

FEV1/FVC ratio increases > 80% (normal or above normal)

Treatment

Anti-inflammatory (may not be very effective)
TGF Beta-blockers
Oxygen
Lung transplant

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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