This lecture provides an overview of proton pump inhibitors (PPIs), a class of medications widely used to suppress gastric acid production. It will cover their mechanism of action, pharmacology, and ADME (Absorption, Distribution, Metabolism, and Excretion). This foundational knowledge will help in understanding their role in managing acid-related disorders. Clinical applications and adverse effects will be addressed in the next lecture.
Learning Objectives:
- Explain the mechanism of action of proton pump inhibitors and their role in acid suppression.
- Describe the pharmacology of PPIs and their interaction with gastric parietal cells.
- Understand the ADME (Absorption, Distribution, Metabolism, and Excretion) characteristics of PPIs.
Proton Pump Inhibitors
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) (p. 3474). McGraw Hill LLC. Kindle Edition.
Faculty
In addition to the presenter, following authors may have helped with the content writing, review,
or approval:
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The DrBeen Corp designates this enduring material for a maximum of 0.75 AMA PRA Category 1
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Physicians should claim only the credit commensurate with the extent of their participation in the
activity.
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| Faculty |
Disclosures |
| Dr. Mobeen Syed |
Author declares no conflict of interest. |
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2 Comments
peterjfw@*.com
Apr 24 2025, 12:34 pm
To continue, we need the acid, and tyhe main reason for reflux is not enough acid. This means the sensor at the top of the tomach doesn't register the acid, so leaves the sphincter open, allowing the acid to splash up into the oesophagus. If you increase the acid by taking betaine hydrochloride or even diluted apple cider vinegar the reflux goes away, without the effects that the pharmaceuticals provide.
peterjfw@*.com
Apr 24 2025, 12:30 pm
Let me try again without touching the send arrow. All these pump inhibitors, and over the counter antacid products are fine, if for instance you want to ease a problem with an ulcer which I understand is a bacterial caused proble, or to help tollerate certain medicines. However GERD, or acid reflux does NOT require substances to reduce acid. Acid is an absolutely necessary part of both protecting the body from pathogens, and also breaking down food for digestion. We need it. The reason why people get reflux, and I had a very bad case where I foolishly had surgical treatment to realign my stomach. A totally unnecessary procedure.