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This lecture provides an overview of proton pump inhibitors (PPIs), a class of medications widely used to suppress gastric acid production. It will cover their mechanism of action, pharmacology, and ADME (Absorption, Distribution, Metabolism, and Excretion). This foundational knowledge will help in understanding their role in managing acid-related disorders. Clinical applications and adverse effects will be addressed in the next lecture.
Learning Objectives:
Proton Pump Inhibitors
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) (p. 3474). McGraw Hill LLC. Kindle Edition.
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
peterjfw@*.com
Apr 24 2025, 12:34 pm
To continue, we need the acid, and tyhe main reason for reflux is not enough acid. This means the sensor at the top of the tomach doesn't register the acid, so leaves the sphincter open, allowing the acid to splash up into the oesophagus. If you increase the acid by taking betaine hydrochloride or even diluted apple cider vinegar the reflux goes away, without the effects that the pharmaceuticals provide.
peterjfw@*.com
Apr 24 2025, 12:30 pm
Let me try again without touching the send arrow. All these pump inhibitors, and over the counter antacid products are fine, if for instance you want to ease a problem with an ulcer which I understand is a bacterial caused proble, or to help tollerate certain medicines. However GERD, or acid reflux does NOT require substances to reduce acid. Acid is an absolutely necessary part of both protecting the body from pathogens, and also breaking down food for digestion. We need it. The reason why people get reflux, and I had a very bad case where I foolishly had surgical treatment to realign my stomach. A totally unnecessary procedure.