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Preprint Study: Spike Protein Accumulates in The Brain

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lorimccoy775@*.com

Jul 21 2023, 5:54 pm

Thank you for this detailed explanation. I watched your video a few months ago about spike crossing the BBB and new this was serious. My daughter had ALL 40 years ago and they had t give her endothelial chemo, explaining that this was the only was to reach the brain with medication due to the chemicles being to large to reach the brain via intravenous. My long gone memory of this explaination was of great use in understanding just how scary this spike protein is.

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mrlori@*.com

Jul 19 2023, 7:24 pm

Make sure the house plant is not a philodendron. They contain calcium oxalate crystals which can kill a cat or dog. Thank you for sharing this sobering information.

Brand New Study: Spike Protein Accumulates in Brain and Skull and Causes Damage

ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of neurological symptoms, including brain fog and brain tissue loss, raising concerns about the virus’s acute and potential chronic impact on the central nervous system. In this study, we utilized mouse models and human post-mortem tissues to investigate the presence and distribution of the SARS-CoV-2 spike protein in the skull-meninges-brain axis. Our results revealed the accumulation of the spike protein in the skull marrow, brain meninges, and brain parenchyma. The injection of the spike protein alone caused cell death in the brain, highlighting a direct effect on brain tissue. Furthermore, we observed the presence of spike protein in the skull of deceased long after their COVID-19 infection, suggesting that the spike’s persistence may contribute to long-term neurological symptoms. The spike protein was associated with neutrophil-related pathways and dysregulation of the proteins involved in the PI3K-AKT as well as complement and coagulation pathway. Overall, our findings suggest that SARS-CoV-2 spike protein trafficking from CNS borders into the brain parenchyma and identified differentially regulated pathways may present insights into mechanisms underlying immediate and long-term consequences of SARS-CoV-2 and present diagnostic and therapeutic opportunities.



SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 | bioRxiv
https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1

SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 | bioRxiv
https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1.full

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice | Nature Neuroscience
https://www.nature.com/articles/s41593-020-00771-8...

Frontiers | Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection
https://www.frontiersin.org/articles/10.3389/fimmu.2021.746021/full?trk=public_post_comment-text

Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae | Clinical Infectious Diseases | Oxford Academic
https://academic.oup.com/cid/article/76/3/e487/6686531?login=false

Brain tissue expression of RHOA - Summary - The Human Protein Atlas
https://www.proteinatlas.org/ENSG00000067560-RHOA/brain

Molecular basis of the structure and function of H1 hemagglutinin of influenza virus - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410141/

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis | Circulation
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025#d1e1289

 

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Dr. Mobeen Syed

Dr. Mobeen Syed

Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.

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