Dr. Syed presents pathological events leading up to the type 1 diabetes mellitus (T1DM). Topics covered are:
+T1DM is an autoimmune disease.
+Role of genetic mutations and allele inheritance for DQ, DR3 and DR4 in the HLA region on chromosome 6p21.
+Role of polymorphism in insulin, CTLA4, and other molecules.
+Role of incorrect T cell training in Thymus.
+Role of cytotoxic T cells in beta cell damage. Leading to insulitis.
+Role of humoral/antibody response causing beta cell damage. Leading to insulitis.
+Incorrect formation of MHC molecules increasing affinity for the self-antigens.
+Other autoimmune diseases that may be present with T1DM.
Learning objectives of this video are the following:
1. Definition of diabetes mellitus type-1.
2. Epidemiology.
3. Concept of normal immune mechanisms for combating an antigen.
4. Abnormalities in these mechanisms.
5. How autoimmune diseases occur?
6. Application of above mentioned concepts to explain pathophysiology diabetes mellitus type-1.
Presented by Dr. Mobeen Syed
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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joseph.p.reo@*.com
Oct 18 2018, 9:49 am
I don’t have access even though I have a lifetime access membership. Please rectify. Thanks.
anmol.agrawal85.aa@*.com
Oct 07 2018, 12:30 pm
I HAVE A LIFE TIME ASSESS STILL NOT ABLE TO OPEN THIS VIDEO. WHYYYYYYYY???