In today's talk we will discuss the following topics:
What are opiates, opioids, and narcotics?
What are endogenous opioids?
Opioid receptor classes.
Opioid receptor distribution.
Opioid receptor ligands, agonists, and antagonists.
Opioid receptor structure.
Opioid receptor signaling.
References and attributions:
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman's the Pharmacological Basis of Therapeutics) (p. 1359). McGraw Hill LLC. Kindle Edition.
Papaver Somniferum image:
By tanja niggendijker from apeldoorn, the netherlands - poppiesUploaded by Epibase, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=8495875
GPCR | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/gpcr-14047471/
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895212/
Untangling the complexity of opioid receptor function | Neuropsychopharmacology
https://www.nature.com/articles/s41386-018-0225-3
Frontiers | Gi/o-Protein Coupled Receptors in the Aging Brain
https://www.frontiersin.org/articles/10.3389/fnagi.2019.00089/full
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action | PNAS
https://www.pnas.org/doi/10.1073/pnas.0508812103
Learning objectives of this video are the following :
1. Understanding the types and structure of opioid receptors.
2. Opioid receptor signaling.
3. Distribution of opioid receptors in brain.
4. Opioid receptor agonist and antagonist drug list.
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
lost2woods@*.com
Jan 20 2024, 5:54 pm
Excellent presentation.
nas@*.com
Jan 05 2024, 10:29 pm
thanks so much , this video clears up a lot of questions I had . love this series , has been a mojor interest for years