Nuclear factor kappa B, or more completely nuclear factor kappa light chain enhancer of activated B cells (NF-κB) is an important inflammatory pathway to learn. It is a set of proteins that make up a family of transcription factors to regulate genes involved in inflammation, immunity, and cell survival. It influences both the innate and acquired arm of our immune system. It plays and key role in regulating the survival, activation and differentiation of innate and adaptive immune cells. In healthy individuals, NF-κB activation is tightly regulated, with a quick response followed by deactivation. Chronic activation of NF-κB due to various factors like infections, toxins, or stress can lead to chronic inflammation.

Objectives:

Why is it called NF-κB?

Understanding the function of NF-κB.

Consequence of chronic activation of NF-κB.

Modulating NF-κB with supplements, lifestyle, food, and pharmaceutical therapies.

Inflammation | DrBeen

https://members.drbeen.com/courses/inflammation/HkvpMzD8A

NF-κB signaling in inflammation | Signal Transduction and Targeted Therapy

https://www.nature.com/articles/sigtrans201723

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy

https://www.nature.com/articles/s41392-020-00312-6

Enhancers: bridging the gap between gene control and human disease - PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061867/#:~:text=Enhancers%20are%20a%20class%20of,and%20in%20terminally%20differentiated%20cells.

Enhancer function: new insights into the regulation of tissue-specific gene expression | Nature Reviews Genetics

https://www.nature.com/articles/nrg2957 Enhancer (genetics) - Wikipedia https://en.wikipedia.org/wiki/Enhancer_(genetics)

Non-canonical NF-κB signaling pathway | Cell Research

https://www.nature.com/articles/cr2010177#:~:text=Non%2Dcanonical%20NF%2D%CE%BAB%20pathway%20relies%20on%20phosphorylation%2Dinduced,activation%20of%20RelB%2Fp52%20complex.

Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial | Scientific Reports

https://www.nature.com/articles/s41598-017-15264-1

Vitamin D Receptor Inhibits Nuclear Factor κB Activation by Interacting with IκB Kinase β Protein - PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707648/

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties - PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372981/

Oxidized Omega-3 Fatty Acids Inhibit NF-κB Activation Via a PPARα-Dependent Pathway | Arteriosclerosis, Thrombosis, and Vascular Biology

https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000137191.02577.86

Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic

https://academic.oup.com/abbs/article/47/3/207/1754742

Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease - PubMed

https://pubmed.ncbi.nlm.nih.gov/30392493/

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