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NK cells originate from the lymphoid progenitors, however, these cells function as the innate arm component. NK cells induce apoptosis in the infected and cancerous cells. NK cells secret perforins and granzymes for this purpose. NK cells are activated by IL-12 from the macrophages and IFN alpha and beta from the infected cells. NK cells can in turn release IFN gamma to activate the macrophages.
References Natural Killer Cells: Development, Maturation, and Clinical Utilization - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099181/
Stem cell - Wikipedia https://en.wikipedia.org/wiki/Stem_cell
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fisher6000@*.com
Feb 26 2023, 9:26 pm
Thank You Dr Been for your great lectures. They are above my level of knowledge, but the art work is amazingly helpful.
rebeccabuckland2020@*.com
Feb 25 2023, 6:48 am
absolutely brilliant teaching - Thank you Dr Been