Today we will discuss the first part of the Naloxone and Naltrexone topics. Naloxone and Naltrexone are synthetic modifications to oxymorphone. Which in turn is derived from morphine. Both naloxone and naltrexone are non-selective, competitive antagonists of the opioid receptors. Their affinity is variable for various types of receptors though. Naloxone is approved for over-the-counter opioid overdose prevention or reversal. It is available in the form of a nasal spray and intravenous preparation. Naltrexone on the other hand is prescription medicine for alcohol and opioid use disorders.
The following points will be discussed (objectives):
Opioid Overdose Management (FDA, DEA, and More)
What are Naloxone and Naltrexone?
Pharmacological properties.
Effects in the absence of opioid agonists.
Effects in the presence of opioid agonists.
Effects in opioid-dependent patients.
Absorption, distribution, metabolism, and elimination (ADME)
FDA Approves First Over-the-Counter Naloxone Nasal Spray | FDA
https://www.fda.gov/news-events/press-announcements/fda-approves-first-over-counter-naloxone-nasal-spray
Save Lives | DEA.gov
https://www.dea.gov/onepill/save-lives#:~:text=Naloxone%20is%20a%20medicine%20that,because%20of%20an%20opioid%20overdose.
Naloxone vs. Naltrexone: How These Opioid Blockers Differ - GoodRx
https://www.goodrx.com/conditions/opioid-use-disorder/naloxone-vs-naltrexone
Naloxone - Wikipedia
https://en.wikipedia.org/wiki/Naloxone
Naltrexone - Wikipedia
https://en.wikipedia.org/wiki/Naltrexone
Structures of morphine, oxymorphone buprenorphine, naloxone and... | Download Scientific Diagram
https://www.researchgate.net/figure/Structures-of-morphine-oxymorphone-buprenorphine-naloxone-and-naltrexone-Message_fig1_274901620
Reversal of opioid overdose syndrome in morphine-dependent rats using buprenorphine - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0378427414015148#:~:text=The%20overshoot%20phenomenon%20may%20result,Olsen%2C%202011%2C%20Hassanian%2DMoghaddam
Basic opioid pharmacology: an update - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590096/
Fentanyl - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK459275/
Frequently Asked Questions for NARCAN® Nasal Spray
https://narcan.com/frequently-asked-questions
Narcan (naloxone): Dosage, uses, side effects, and more
https://www.medicalnewstoday.com/articles/narcan#side-effects
* Understand opioid overdose management, including FDA and EDA guidelines.
* Define Naloxone and Naltrexone and their roles in opioid reversal.
* Describe the pharmacological properties of Naloxone and Naltrexone.
* Identify the effects of Naloxone and Naltrexone in the absence of opioid agonists.
* Recognize the effects of Naloxone and Naltrexone in the presence of opioid agonists.
* Explain the effects of Naloxone and Naltrexone in opioid-dependent patients.
* Discuss the absorption, distribution, metabolism, and elimination of Naloxone and Naltrexone
No credit card information needed.
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
rpjseb@*.com
May 24 2024, 4:48 pm
Anyone actually figured out the CME bit? My record just shows 0!!!
tjm8922@*.com
May 22 2024, 3:04 pm
I see the answer to my question at 35 minutes