WHO's list of essential medicines: safest and most effective drug needed in the health system.
Used for acetaminophen/paracetamol overdose and to loosen thick mucus.
Appears to be safe in pregnancy
How does NAC break disulfide bonds?
https://www.researchgate.net/figure/Structural-formula-of-N-acetylcysteine-NAC-A-Disulfide-bonds-in-proteins-P-can-be_fig1_299401240
It increases the levels of glutathione in paracetamol overdose.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/
Role of glutathione in immunity and inflammation in the lung
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048347/
Disulfide bond reduction of vWF
https://www.ncbi.nlm.nih.gov/pubmed/20946172
N-Acetylcysteine as an antioxidant and disulfide breaking agent: the reasons why
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1468564
NAC functions
https://www.sciencedirect.com/topics/chemistry/cysteine
In this talk, we are going to discuss the following topics:
Presented by Dr. Mobeen Syed
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Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
govender@*.com
May 07 2021, 4:09 pm
Brilliant insights simply explained.
imuzaffar@*.com
Jul 07 2020, 3:14 am
Dr Syed, thank you for a very informative lecture on NAC. I would like to have your comment on some of these warning shots re NAC as well. https://blogs.sciencemag.org/pipeline/archives/2019/10/04/n-acetyl-cysteine-a-warning-shot