MTHFR Enzyme Deficiency and Cardiovascular Health

In this talk, we will review folate, tetrahydrofolate, 4-10 methionine THF, homocysteine, s-adenosyl homocysteine, s-adenosyl methionine, and metabolisms. We will also go over the importance of the methionine tetrahydrofolate reductase (MTHFR) enzyme deficiency and its association with cardiovascular system pathologies, and fetal neurological developmental abnormalities. We will especially look at the increased association with clotting in individuals with MTHFR mutated enzyme. We will also see the two common mutations and their high-level epidemiology. We will discuss how vitamins B6, B9 (folate or folic acid) and B12 can help reduce homocysteine levels.

Homocysteine and MTHFR Mutations | Circulation
https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311

preprints202303.0418.v2.pdf
file:///C:/Users/s_mob/Downloads/preprints202303.0418.v2.pdf

Folate, MTHFR Gene and Heart Health
https://www.gbhealthwatch.com/GND-Cardiovascular-Diseases-MTHFR.php

Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/

Frontiers | Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
https://www.frontiersin.org/articles/10.3389/fphar.2020.587451/full

Methylenetetrahydrofolate Reductase Deficiency - Medical Genetics Summaries - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK66131/

Contribution of genotypes in Prothrombin and Factor V Leiden to COVID‐19 and disease severity in patients at high risk for hereditary thrombophilia - Kiraz - 2023 - Journal of Medical Virology - Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28457

Do MTHFR polymorphisms make you more susceptible to COVID-19? - MTHFR Support Australia
https://mthfrsupport.com.au/2021/08/do-mthfr-polymorphisms-make-you-more-susceptible-to-covid-19/

Acute Macular Neuroretinopathy Associated With COVID-19 Infection: Is Double Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutation an Underlying Risk Factor? - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968507/

Methylenetetrahydrofolate reductase - Wikipedia
https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase