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MTHFR Enzyme Deficiency and Cardiovascular Health

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In this talk, we will review folate, tetrahydrofolate, 4-10 methionine THF, homocysteine, s-adenosyl homocysteine, s-adenosyl methionine, and metabolisms. We will also go over the importance of the methionine tetrahydrofolate reductase (MTHFR) enzyme deficiency and its association with cardiovascular system pathologies, and fetal neurological developmental abnormalities. We will especially look at the increased association with clotting in individuals with MTHFR mutated enzyme. We will also see the two common mutations and their high-level epidemiology. We will discuss how vitamins B6, B9 (folate or folic acid) and B12 can help reduce homocysteine levels.

Homocysteine and MTHFR Mutations | Circulation


Folate, MTHFR Gene and Heart Health

Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate - PMC

Frontiers | Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism

Methylenetetrahydrofolate Reductase Deficiency - Medical Genetics Summaries - NCBI Bookshelf

Contribution of genotypes in Prothrombin and Factor V Leiden to COVID‐19 and disease severity in patients at high risk for hereditary thrombophilia - Kiraz - 2023 - Journal of Medical Virology - Wiley Online Library

Do MTHFR polymorphisms make you more susceptible to COVID-19? - MTHFR Support Australia

Acute Macular Neuroretinopathy Associated With COVID-19 Infection: Is Double Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutation an Underlying Risk Factor? - PMC

Methylenetetrahydrofolate reductase - Wikipedia

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