We will discuss the effects of systemic administration of opioids by their actions on the brain, spinal cord, and in some instances periphery. The following topics will be covered:
1. Supraspinal actions.
2. Spinal opioid actions.
3. Peripheral actions.
4. Neurotransmitters released in the supraspinal and spinal pathways.
Mood Alterations and Rewarding Properties
Reference: Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman's the Pharmacological Basis of Therapeutics) (p. 1376). McGraw Hill LLC. Kindle Edition.
* Recognize opioid mechanisms in pain modulation at supraspinal, spinal, and peripheral levels.
* Identify the pivotal role of Mesencephalic Periaqueductal Gray (PAG) in supraspinal opioid analgesia.
* Analyze the clinical implications of opioid-induced disinhibition of the medullospinal tract.
* Explore the effects of opioids at spinal levels, encompassing calcium channel modulation, neurotransmitter release, and hyperpolarization.
*Recognize direct opioid effects on peripheral pain thresholds.
Faculty
In addition to the presenter, following authors may have helped with the content writing, review,
or approval:
CME, CE, CEU and Other Credit Types:
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Physicians should claim only the credit commensurate with the extent of their participation in the
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All members of the Activity Planning Committee and presenters have disclosed their relevant financial
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| Faculty |
Disclosures |
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Author declares no conflict of interest. |
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1 Comments
kakavand@*.com
Jan 17 2024, 7:44 pm
Please give me the CMEs. Thank you.