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Mast and Basal Cells (Part 3)

Duration: 10:40

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fwwmee@*.com

Mar 05 2020, 9:49 am

Nevermind, I misunderstood. cGMP is the second messenger that causes degranulation. cAMP blocks the Ca2+ channels pathways and stabilizies the mast cell.

My mistake.

mobeen@*.com

Mar 04 2020, 7:55 pm

Thank you for studying so diligently. We need more of you 🎉🎉🎉

fwwmee@*.com

Mar 05 2020, 9:42 am

Here you say that the confirmational change brought by the two IgEs would cause increased production of cGMP. However, during your lecture on hypersensitivity type 1, (@33:55) you mention that the increased production of cAMP is what causes the granules to preprare for degranulation. I am wondering which one is really at play here.

Thank you for your wonderful lectures.

rlevatter@*.com

Sep 10 2023, 8:00 pm

CONFORMATIONAL...Changes in the conformation (shape) of the protein.

In this lecture Dr. Mobeen will discuss:
1. How IgE antibodies mediate anaphylaxis. (00:28)
2. Role of cGMP in relese of histamine. (3:20)
3. The mechanism of action of histamine. (5:00)
4. cAMP and its function in membrane stabilization of mast cells. (7:44)

Presented by Dr. Mobeen Syed

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Immunology

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