In this lecture Dr. Mobeen will discuss:
1. How IgE antibodies mediate anaphylaxis. (00:28)
2. Role of cGMP in relese of histamine. (3:20)
3. The mechanism of action of histamine. (5:00)
4. cAMP and its function in membrane stabilization of mast cells. (7:44)
Presented by Dr. Mobeen Syed
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2 Comments
fwwmee@*.com
Mar 05 2020, 9:49 am
Nevermind, I misunderstood. cGMP is the second messenger that causes degranulation. cAMP blocks the Ca2+ channels pathways and stabilizies the mast cell.
My mistake.
fwwmee@*.com
Mar 05 2020, 9:42 am
Here you say that the confirmational change brought by the two IgEs would cause increased production of cGMP. However, during your lecture on hypersensitivity type 1, (@33:55) you mention that the increased production of cAMP is what causes the granules to preprare for degranulation. I am wondering which one is really at play here.
Thank you for your wonderful lectures.