In this lecture Dr. Mobeen will discuss:
1. How IgE antibodies mediate anaphylaxis. (00:28)
2. Role of cGMP in relese of histamine. (3:20)
3. The mechanism of action of histamine. (5:00)
4. cAMP and its function in membrane stabilization of mast cells. (7:44)
Presented by Dr. Mobeen Syed
No credit card information needed.
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
fwwmee@*.com
Mar 05 2020, 9:49 am
Nevermind, I misunderstood. cGMP is the second messenger that causes degranulation. cAMP blocks the Ca2+ channels pathways and stabilizies the mast cell.
My mistake.
fwwmee@*.com
Mar 05 2020, 9:42 am
Here you say that the confirmational change brought by the two IgEs would cause increased production of cGMP. However, during your lecture on hypersensitivity type 1, (@33:55) you mention that the increased production of cAMP is what causes the granules to preprare for degranulation. I am wondering which one is really at play here.
Thank you for your wonderful lectures.