Maraviroc Mechanism of Action (MOA)
Maraviroc is a potential antiviral drugs for the HIV-1 (R5 strain). Let’s review it’s mechanism of action. (See the side effects in the video and the description below. Also, review the references.)
About serious side effects of Maraviroc (Reference: https://clinicalinfo.hiv.gov/en/drugs/maraviroc/patient)
Note: Maraviroc can cause serious, life-threatening side effects. These include liver problems and severe skin rash and allergic reactions.
References:
Maraviroc
https://en.wikipedia.org/wiki/Maraviroc
Book: Goodman and Gilman
Maraviroc blocks the binding of the HIV outer envelope protein gp120 to the CCR5 chemokine receptor
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) . McGraw-Hill Education. Kindle Edition.
Location 54074
CCR5
https://en.wikipedia.org/wiki/CCR5
On monocytes
https://journals.lww.com/shockjournal/Fulltext/2019/11000/CCR5_Positive_Inflammatory_Monocytes_are_Crucial.16.aspx
CCR5 and Cytotoxic T cells
https://pubmed.ncbi.nlm.nih.gov/31034775/
CCR5 Receptor Antagonists
https://en.wikipedia.org/wiki/CCR5_receptor_antagonist#Drug_development
HIV.Gov
https://clinicalinfo.hiv.gov/en/drugs/maraviroc/patient
G-protein coupled receptors
https://en.wikipedia.org/wiki/G_protein-coupled_receptor
CCL5
https://en.wikipedia.org/wiki/CCL5
In this lecture Dr. Mobeen will discuss:
1. Overview of the lecture. (1:19)
2. Introduction to maraviroc. (4:09)
3. Mechanism of the drug. (5:24)
4. Role of CCR5 in the mechanism of maraviroc. (13:57)
5. Regulated on activation normal T cell expressed and secreted. (RANTES/CCL5) (18:20)
6. Brief summary of HIV virus. (20:36)
7. Action of maraviroc against HIV. (26:36)
8. Side effects of maraviroc. (29:57)
No credit card information needed.
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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