This is the first part of the lab series for sickle cell diseases. Our kool beens have asked for this series for a long time.

In this recording of the FB live talk, we will discuss the following topics:

1. Red blood cells (RBCs)
2. RBCs function
   1. Oxygen transport via hemoglobin transport
   2. Carbon dioxide transport
   3. Buffering system for blood
3. RBCs lifetime
4. RBCs production sites
   1. Intrauterine life
      1. Liver
      2. Yolk sac
      3. Others
   2. Early life
      1. Long bone marrow (tibia, femur)
   3. Adult
      1. Membranous bones
         1. Vertebrae (primary manufacturers)
         2. Clavicle
         3. Sternum
         4. Ribs
         5. Iliac crests
5. Stages of the RBCs from formation to the destruction
   1. Totipotent STEM cells. (RBCs parent cells)
   2. Pluripotent Hematopoietic STEM cells
   3. Colony-forming unit spleen (CFU-S)
   4. Colony-forming unit blast cells (CFU-B)
   5. Colony-forming unit erythroblast (CFU-E)
   6. Pro-erythroblast
   7. Reticulocytes
   8. Erythrocytes (mature RBCs.)
6. Percentage of RBC life stages in the peripheral blood picture