In this lecture we will discuss ibuprofen, its uses, ADME, side effects, and the toxicity.
Objectives:
Ibuprofen - class of NSAID
Mechanism of action
Clinical indications
Possible side-effects to be aware of
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes | FDA
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-strengthens-warning-non-aspirin-nonsteroidal-anti-inflammatory
Ibuprofen and Aspirin: Microsoft Word - Science Paper10 IBU MMcomments 052606.doc
https://www.fda.gov/media/76636/download
1.6. Ibuprofen | Therapeutic Goods Administration (TGA)
https://www.tga.gov.au/resources/publication/scheduling-decisions-interim/scheduling-delegates-interim-decisions-and-invitation-further-comment-accsacms-november-2017/16-ibuprofen
Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo | Human Reproduction | Oxford Academic
https://academic.oup.com/humrep/article/33/3/482/4831088
Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data | The BMJ
https://www.bmj.com/content/357/bmj.j1909#:~:text=With%20use%20for%20one%20to,diclofenac%2C%20naproxen%2C%20and%20rofecoxib.
NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC4592725/#sec3
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC6513618/
Ibuprofen and cardiovascular safety
https://www.medsafe.govt.nz/safety/ews/2015/Ibuprofen.asp
Frontiers | Kidney Injury Following Ibuprofen and Acetaminophen: A Real-World Analysis of Post-Marketing Surveillance Data
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.750108/full
Renal Effects of Prostaglandins and Cyclooxygenase-2 Inhibitors - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC3894486/#:~:text=Prostaglandins%20(PGs)%20with%20best%2D,flow%20and%20secretion%20of%20potassium.
Acute Kidney Injury - Part 1
https://www.abdn.ac.uk/medical/elf/courses/view/145980/acute-kidney-injury-part-1/1/page13
Stereoselective and domain-specific effects of ibuprofen on the thermal stability of human serum albumin - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0928098717306425
In this lecture we will discuss ibuprofen, its uses, ADME, side effects, and the toxicity.
Objectives:
Ibuprofen - class of NSAID
Mechanism of action
Clinical indications
Possible side-effects to be aware of
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Write A New Comment
2 Comments
drelyndalandry@*.com
Dec 02 2024, 5:33 am
Liver fibrosis
mauro@*.com
Nov 28 2024, 7:08 pm
Very intense but clearly equally important lecture. Thank You.