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In this lecture we will discuss ibuprofen, its uses, ADME, side effects, and the toxicity.
Objectives:
Ibuprofen - class of NSAID
Mechanism of action
Clinical indications
Possible side-effects to be aware of
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes | FDA
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-strengthens-warning-non-aspirin-nonsteroidal-anti-inflammatory
Ibuprofen and Aspirin: Microsoft Word - Science Paper10 IBU MMcomments 052606.doc
https://www.fda.gov/media/76636/download
1.6. Ibuprofen | Therapeutic Goods Administration (TGA)
https://www.tga.gov.au/resources/publication/scheduling-decisions-interim/scheduling-delegates-interim-decisions-and-invitation-further-comment-accsacms-november-2017/16-ibuprofen
Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo | Human Reproduction | Oxford Academic
https://academic.oup.com/humrep/article/33/3/482/4831088
Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data | The BMJ
https://www.bmj.com/content/357/bmj.j1909#:~:text=With%20use%20for%20one%20to,diclofenac%2C%20naproxen%2C%20and%20rofecoxib.
NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC4592725/#sec3
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC6513618/
Ibuprofen and cardiovascular safety
https://www.medsafe.govt.nz/safety/ews/2015/Ibuprofen.asp
Frontiers | Kidney Injury Following Ibuprofen and Acetaminophen: A Real-World Analysis of Post-Marketing Surveillance Data
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.750108/full
Renal Effects of Prostaglandins and Cyclooxygenase-2 Inhibitors - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC3894486/#:~:text=Prostaglandins%20(PGs)%20with%20best%2D,flow%20and%20secretion%20of%20potassium.
Acute Kidney Injury - Part 1
https://www.abdn.ac.uk/medical/elf/courses/view/145980/acute-kidney-injury-part-1/1/page13
Stereoselective and domain-specific effects of ibuprofen on the thermal stability of human serum albumin - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0928098717306425
In this lecture we will discuss ibuprofen, its uses, ADME, side effects, and the toxicity.
Objectives:
Ibuprofen - class of NSAID
Mechanism of action
Clinical indications
Possible side-effects to be aware of
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
drelyndalandry@*.com
Dec 02 2024, 5:33 am
Liver fibrosis
mauro@*.com
Nov 28 2024, 7:08 pm
Very intense but clearly equally important lecture. Thank You.