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H2 Receptor Antagonists - Clinical Use and Side Effects

Duration: 20:13

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deborahdenisesharp@*.com

Mar 28 2025, 11:17 am

Hi - The video says it cannot be viewed "because of privacy settings". (?)

H2 receptor antagonists (H2RAs) function by competitively inhibiting histamine binding at H2 receptors on gastric parietal cells, thereby reducing gastric acid secretion. This pharmacological class includes famotidine, nizatidine, cimetidine, and ranitidine (though ranitidine was withdrawn from the US market in 2020 due to NDMA contamination concerns).
H2RAs are indicated for various acid-related disorders including gastroesophageal reflux disease (GERD), peptic ulcer disease (both gastric and duodenal), prevention of NSAID-induced gastropathy, stress ulcer prophylaxis in critically ill patients, and management of hypersecretory conditions such as Zollinger-Ellison syndrome. They also provide symptomatic relief for non-ulcer dyspepsia and can be used perioperatively to reduce aspiration risk.

While generally well-tolerated, H2RAs may cause adverse effects including headache, dizziness, fatigue, constipation, and diarrhea. Cimetidine notably inhibits cytochrome P450 enzymes, resulting in significant drug interactions. Rare but serious adverse effects include altered mental status in elderly patients, thrombocytopenia, and hepatotoxicity.

Lecture Objectives:
List the primary clinical applications of H2 blockers.
Identify the common and less common side effects associated with H2 receptor antagonist use.

List the primary clinical applications of H2 blockers.
Identify the common and less common side effects associated with H2 receptor antagonist use.

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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Dr. Mobeen Syed

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The DrBeen Corp designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Faculty	Disclosures
Dr. Mobeen Syed	Author declares no conflict of interest.

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Dr. Mobeen Syed

MD., MSc., MSc., BSc

Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.

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