In this lecture, we will explore the physiological and pathological effects of Angiotensin II, a key effector of the renin-angiotensin-aldosterone system (RAAS). Based on Goodman & Gilman, we will examine three major domains of Angiotensin II action:
Altered Peripheral Resistance – including vasoconstriction and enhanced sympathetic activity
Altered Renal Function – focusing on sodium reabsorption, aldosterone release, and renal hemodynamics
Altered Cardiovascular Structure – covering hypertrophy and remodeling effects
Objectives:
- Understand the mechanisms by which Angiotensin II influences vascular tone, renal function, and cardiac structure
- Identify the acute and chronic outcomes of Angiotensin II signaling
- In the next lecture, we will link these effects to therapeutic targets of ACE inhibitors and ARBs
Functions and Effects of Angiotensin II
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) (p. 1825). McGraw Hill LLC. Kindle Edition.
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1 Comments
anusuya@*.com
Jul 16 2025, 1:16 pm
Hey