In this talk, Dr. Syed presents the model for insulin resistance presented by Dr. Barbara E. Corkey. She was awarded the Banting Lecture 2011 award for her article: Hyperinsulinemia: Cause or Consequence? Based on her groundbreaking model there have been many approaches to attempt to reverse type II diabetes mellitus (T2DM). We will look at the evidence of T2DM reversal, and then go over the highlights of various studies that have demonstrated the T2DM reversal using varying approaches.
Frederick Banting - Wikipedia
https://en.wikipedia.org/wiki/Frederick_Banting
Barbara Corkey | Chobanian & Avedisian School of Medicine
https://www.bumc.bu.edu/busm/profile/barbara-corkey/
Banting Lecture 2011 | Diabetes | American Diabetes Association
https://diabetesjournals.org/diabetes/article/61/1/4/15978/Banting-Lecture-2011Hyperinsulinemia-Cause-or
Insulin Resistance & Prediabetes - NIDDK
https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance
Banting Lecture 2011 | Diabetes | American Diabetes Association
https://diabetesjournals.org/diabetes/article/61/1/4/15978/Banting-Lecture-2011Hyperinsulinemia-Cause-or
Bariatric Surgery for Type 2 Diabetes Reversal: The Risks | Diabetes Care | American Diabetes Association
https://diabetesjournals.org/care/article/34/Supplement_2/S361/28238/Bariatric-Surgery-for-Type-2-Diabetes-Reversal-The
Bariatric Surgery to Treat Type 2 Diabetes
https://my.clevelandclinic.org/health/treatments/21153-bariatric-weight-loss-surgery-for-treating-diabetes
Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report | Diabetes Care | American Diabetes Association
https://diabetesjournals.org/care/article/42/5/731/40480/Nutrition-Therapy-for-Adults-With-Diabetes-or
International Experts Outline Diabetes Remission Diagnosis Criteria | ADA
https://diabetes.org/newsroom/press-releases/2021/international-experts-outline-diabetes-remission-diagnosis-criteria
Nutritional basis of type 2 diabetes remission | The BMJ
https://www.bmj.com/content/374/bmj.n1449
Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PubMed
https://pubmed.ncbi.nlm.nih.gov/30301822/
Case Report: Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194375/
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years - PubMed
https://pubmed.ncbi.nlm.nih.gov/33521540/
HbA1c Calculator - HbA1c
https://www.hba1cnet.com/hba1c-calculator/
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841829/
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - PubMed
https://pubmed.ncbi.nlm.nih.gov/29221645/
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - CORE Reader
https://core.ac.uk/reader/196576423
NIH study finds heavily processed foods cause overeating and weight gain | National Institutes of Health (NIH)
https://www.nih.gov/news-events/news-releases/nih-study-finds-heavily-processed-foods-cause-overeating-weight-gain
Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine | The American Journal of Clinical Nutrition | Oxford Academic
https://academic.oup.com/ajcn/article/71/6/1511/4729485?login=false
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism1,2 - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S000291652327495X?via%3Dihub
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MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
md.talkmani@*.com
Apr 04 2024, 7:47 am
The idea that insulin is a storage hormone and in presence of insulin fat loss can not take place is interesting. It is a nice looking theory. What about its evidence? If somehow we could find papers which matched calories and compared the weight loss between low carb and high carb(insulinogenic) diet, maybe we could get answers. The best part is that we have such studies which clearly shows that the idea even though mechanistically sounds great, does not have much merit. Eucaloric weight loss protocols results in very similar weight loss irrespective of dietary macro distribution. Low carb diets have some advanatages in the first six months but not beyond one year. I encourage you to read the works of one of Kevin D hall.
kmniec57@*.com
Dec 26 2023, 7:07 pm
Thank you so much Dr. Syed!!! Excellent presentation!!!