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Epstein Barr Virus (EBV) Serology

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Epstein Barr Virus (EBV) Serology

Let’s review the serology of the Epstein Barr Virus (EBV). EBV causes Infectious Mononucleosis. This disease is usually benign and self limiting. However, in some cases it can become chronic, or reactivating. EBV can also cause cancers and other serious complications. Let’s review the serology of the EBV.

About infectious Mononucleosis

CDC on EBV Serology

Serological diagnosis of Epstein-Barr virus infection: Problems and solutions

The Relationship Between Environmental Factors and the Profile of Epstein-Barr Virus Antibodies in the Lytic and Latent Infection Periods in Healthy Populations from Endemic and Non-Endemic Nasopharyngeal Carcinoma Areas in China

Epstein-Barr virus (EBV), Infectious Mononucleosis

High level overview of the serology
States of a person:
Susceptible to EBV (never had it before.)
No antibodies

Acute infection

Acute infection late acute
VCA-IgM and increasing VCA-IgG

Past infection
VCA-IgG and EBNA-1 IgG

Reactivation of the EBV
High EA (D) IgG
Increasing VCA-IgG
Decreasing EBNA-1 IgG
Even VCA-IgM may reappear during the reactivation

Immunosuppressed may have
Only EBVCA IgG without EBVCA IgM or EBNA-1

In 1.7% of the infected patients may only show EBNA-1 without EBVCA-IgG (this pattern is usually thought to be implausible.)

Antibody patterns and causes from LabPedia

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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