Epstein Barr Virus (EBV) Serology
Let’s review the serology of the Epstein Barr Virus (EBV). EBV causes Infectious Mononucleosis. This disease is usually benign and self limiting. However, in some cases it can become chronic, or reactivating. EBV can also cause cancers and other serious complications. Let’s review the serology of the EBV.
About infectious Mononucleosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670567/
CDC on EBV Serology
https://www.cdc.gov/epstein-barr/laboratory-testing.html
Serological diagnosis of Epstein-Barr virus infection: Problems and solutions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782265/
The Relationship Between Environmental Factors and the Profile of Epstein-Barr Virus Antibodies in the Lytic and Latent Infection Periods in Healthy Populations from Endemic and Non-Endemic Nasopharyngeal Carcinoma Areas in China
https://www.thelancet.com/article/S2352-3964(18)30073-2/fulltext
Epstein-Barr virus (EBV), Infectious Mononucleosis
https://labpedia.net/epstein-barr-virus-ebv-infectious-mononucleosis/
High level overview of the serology
States of a person:
Susceptible to EBV (never had it before.)
No antibodies
Acute infection
VCA IgM
Acute infection late acute
VCA-IgM and increasing VCA-IgG
Past infection
VCA-IgG and EBNA-1 IgG
Reactivation of the EBV
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782265/
High EA (D) IgG
Increasing VCA-IgG
Decreasing EBNA-1 IgG
Even VCA-IgM may reappear during the reactivation
Immunosuppressed may have
Only EBVCA IgG without EBVCA IgM or EBNA-1
In 1.7% of the infected patients may only show EBNA-1 without EBVCA-IgG (this pattern is usually thought to be implausible.)
Antibody patterns and causes from LabPedia
https://labpedia.net/epstein-barr-virus-ebv-infectious-mononucleosis/
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1 Comments
ssp0315@*.com
Jan 30 2024, 2:04 am
I suggest everyone who has EBV reactivated by the mRNA vaccine file a report on the federal government’s Vaccine Adverse Event Reporting System. We have been shafted, some of us our lives ruined, because we did the right thing. If all of us file a report, I can hope we will get their attention. And the “hhs.gov” address makes me think it might not go to CDC or NIH, both of which have powerful incentives to squash them.