Elevated Interleukin 6 (IL-6) and Normal C Reactive Protein (CRP)

A common question during the COVID-19 pandemic from the long COVID patients is that my interleukin 6 (IL-6) is elevated for months or years but my c reactive protein (CRP) is back to normal. In this talk, we will review a study of hospitalized patients with a discordant IL-6 and CRP.

In addition to the review of the study, we will also briefly review the functions of the CRP other than its use as a blood biomarker for inflammation.

URL list from Tuesday, May. 23 2023
Frontiers | Biomarkers in long COVID-19: A systematic review
https://www.frontiersin.org/articles/10.3389/fmed.2023.1085988/full?utm_source=substack&utm_medium=email#F4

JCM | Free Full-Text | Discrepancy of C-Reactive Protein, Procalcitonin and Interleukin-6 at Hospitalization: Infection in Patients with Normal C-Reactive Protein, Procalcitonin and High Interleukin-6 Values
https://www.mdpi.com/2077-0383/11/24/7324

Function of C-reactive protein - PubMed
https://pubmed.ncbi.nlm.nih.gov/10852144/

Normal CRP levels (and how to lower CRP levels)
https://www.singlecare.com/blog/normal-crp-levels/

What is Fc Receptor | Sino Biological
https://www.sinobiological.com/research/fc-receptor#:~:text=Fc%20receptors%20are%20found%20on,(e.g.%2C%20B%20cells).