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Diabetic Tissue Damage (Managing Type II Diabetes Mellitus - Part 4. Webinar)

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In this session Dr. Mobeen discusses how chronically elevated blood glucose levels cause tissue damage.

Following pathological mechanisms are discussed:

  • Non-enzymatic glycosylation or glycation.
    • Advanced glycation end products (AGE) are discussed.
    • Extracellular matrix thickening and fibrosis is discussed.
    • Tunica intima damage and the acceleration of atheroma formations is discussed.
    • Micro and macro vascular damage.
    • Neuropathies due to microvascular pathologies.
    • Activation of the inflammatory processes due to glycation is reviewed.
    • Renal tissue damage is discussed.
    • Formation of the HbA1c is discussed.
    • Albumin glycation is discussed.
  • Activation of the protein kinase C (PKC) and tissue damage due to the raised levels of the PKC.
    • Diacylglyceroal (DAG) pathway is presented.
    • Elevated glucose levels leading to increased formation of the DAG.
    • Angiogenesis/Neovascularization due to the eleveated DAG. This leads to retinal pathologies.
    • Tumor growth factor beta (TGF-beta) levels increased leading to increased formation of the extracellular matrix. This in turn leads to the thickening of the skin and other tissues.
  • Polyol pathway acceleration and osmotic damage due to sorbitol accumulation in various tissues.
    • Sorbitol accumulation.
    • Increased working of the polyol pathway allows reactive oxygen species to accumulate and cause damage.
    • Myeline sheath pathologies due to the osmotic damage.

In this webinar Dr. Mobeen will discuss:

1. The fate of glucose (hyperglycaemia) in the human body. (recap) (00:38)

2. Mechanism of damage in Diabetes mellitus. (3:08)

3. Glycation mechanism of tissue damage. (6:00)

4. Hyperglycaemia and advanced glycation end product (AGE). (7:51)  

5. AGE and vascular dysfunction. (11:05)

6. Renal dysfunction due to chronic hyperglycaemia. (18:13)

7. PKC activation related tissue damage. (22:44)

8. Polyol pathway acceleration. (29:23)

9. Concept behind autonomic dysfunction in diabetes. (35:56)

Presented by Dr. Mobeen Syed

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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