COVID-19 Primarily A Vascular Disease

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Researchers have discovered the mechanism of the endothelial cell damage caused by the spike protein of the SARS-COV-2. Let’s review this research paper.

Research paper
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Down-regulation of ACE 2
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902

A good summary of the study
The novel coronavirus’ spike protein plays additional key role in illness
https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/

eNOS and Nitric Oxide (NO) functions
https://en.wikipedia.org/wiki/Endothelial_NOS

Mitochondrial fission
https://en.wikipedia.org/wiki/Mitochondrial_fission

A study has revealed that the spike proteins are not only necessary for the SARS-COV-2 to bind to the ACE2 enzyme, but these proteins are also a key factor in causing vascular endothelial damage. Let's review the study and the results.

We will discuss:

Study design.
Role of the spike proteins other than helping SARS-COV-2 to enter a cell.
Spike protein attachment to ACE2 to crate an inflammatory imbalance.
Spike protein attachment to ACE2 to disrupt nitric oxide production.
Local vasoconstriction due to spike proteins and its results.

Presented by Dr. Mobeen Syed

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

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