COVID-19 and Sickle Cell, Thalassemia, and Hemophilia (Full Session)

SARS-COV-2 and blood disorders

https://hemophilianewstoday.com/information-about-covid-19-for-hemophilia-patients/

What are inhibitors?

https://www.feiba.com/us/patient/hemophilia-inhibitors

For example factors VIII or IX clotting factors for hemophilia

Are patients with blood disorders at a higher risk?

Some patients with hemophilia may develop inhibitors and doctors may prescribe them immunosuppressants. These are medicines that suppress the immune system. They may, therefore, make patients more susceptible to infections including SARS-CoV-2.

Plasma therapy is safe from SARS-COV-2 pathogen transmission. Statement by HFA

https://www.hemophiliafed.org/news-stories/2020/03/plasma-protein-therapeutics-association-updated-statement-regarding-coronavirus/

PPTA Statement

https://www.pptaglobal.org/media-and-information/ppta-statements/1055-2019-novel-coronavirus-2019-ncov-and-plasma-protein-therapies

WORLD FEDERATION OF HEMOPHILIA RECOMMENDATIONS FOR HEMOPHILIA PATIENTS

https://www.hemophiliafed.org/news-stories/2020/03/world-federation-of-hemophilia-recommendations-for-hemophilia-patients/

Pandemic and hemoglobin disorders

Sickle cell anemia

Cell sickling in the hypoxic and acidic environment leading to the acute chest syndrome. Plus carboxyamide is mild immunosuppressant that may results in additional risk.

https://www.thalassemia.org/boduw/wp-content/uploads/2020/03/COVID-19-pandemic-and-haemoglobin-disorders_V2.pdf?__cf_chl_jschl_tk__=764a85856edbb5277a06a1c3c87ca9b7e0b49e6d-1589051509-0-Abe-j8o6Rzg3h049qyF_ddqkWDqhgebQLjG1o8390qmQu6_dFzpNjey2hVgV0BQa2RbQRVOBExkb9VdjMTT1bTg_zcvSbhOIZrh98-HkeIZW9jLyJOaUNTX-QVPrFoqJ8SCATKdUcLmnWRWyp2E5kU6n2GPg8fip_6XFf18uLY9fM2Ef45L65yjHhAyE_0aSTwF0B99q5Ivk0JV_WWZAGHZgp4vcbt_2IHqbinjwkUwxBw9D4zzGvdD7Npcc8nxL7ucH79x2BU_D8CXQ2kLMezf11xtbN4DrVQk-zl3XCcEn4jcwKtI6tKGRbcmcRqmgOsq_RrN8T2OEGQUxBhPtgv_ty6oNERuTgpapoO3nzjckPlFqE-UUuIdLLF13WfNxjQ

Hemophilia and COVID-19

von Willebrand Disease and Hemophilia A

https://news.wfh.org/world-federation-of-hemophilia-statement-update-to-covid-19/

Hypercoagulopathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156948/

Desmopressin (DDAVP)

https://en.wikipedia.org/wiki/Desmopressin

G6PD deficiency and COVID-19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166036/

How I treat vWF disease

https://ashpublications.org/blood/article/97/7/1915/53343/How-I-treat-patients-with-von-Willebrand-disease