A Teenage Girl's Incurable Cancer is Cured

A teenage girl Alyssa with incurable leukemia was given a 3 base edited CAR-T cell intervention. Six months after she has no signs of cancer anymore. Let's look at the technology and its application.

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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Thursday, Dec. 15 2022

Base editing: Revolutionary therapy clears girl's incurable cancer - BBC News
https://www.bbc.com/news/health-63859184

'Living drug' offers hope to terminal blood cancer patients - BBC News
https://www.bbc.com/news/health-48706822

CAR T cell - Wikipedia
https://en.wikipedia.org/wiki/CAR_T_cell

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma | NEJM
https://www.nejm.org/doi/10.1056/NEJMoa1707447

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage | Nature
https://www.nature.com/articles/nature17946.epdf?sharing_token=Ayk5lsRJNTXZhNCDFbyzQdRgN0jAjWel9jnR3ZoTv0OOBdtbpUtFghvd4aJsTYA4jDbMWRsLFRXQC5G7bexHTsT1hCyBc5Mec-3i6nrNAK0LO7r2sQnIo0SsK5v0q4_kjeed_tm7MjoxQZ1Hve_RHTm5dwaXE9XoG63kNhO67h4VjDMrZtSpqIwvLG8pCPcK3VwsFjOri6qe_6lTZZvQCQ%3D%3D&tracking_referrer=www.bbc.com

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage | Nature
https://www.nature.com/articles/nature17946

GOSH delivers world-first treatment for Leukaemia | Base editing and CAR T-cell Therapy | Great Ormond Street Hospital | Great Ormond Street Hospital
https://www.gosh.nhs.uk/news/gosh-patient-receives-world-first-treatment-for-her-incurable-t-cell-leukaemia/

David R. Liu on Twitter: "Alyssa, a 13-year old T-cell leukemia (ALL) patient in the UK, was the first person to receive a base editing therapeutic—T cells with three base edits—and the first patient reported to benefit from base editing: complete remission, 6 months later. 1/3 https://t.co/CgL6mD6U7B" / Twitter
https://twitter.com/davidrliu/status/1601770994070597632

CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets - PubMed
https://pubmed.ncbi.nlm.nih.gov/12594257/

CD19 - Wikipedia
https://en.wikipedia.org/wiki/CD19

Pathogenesis and prognostication in acute lymphoblastic leukemia - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108947/

CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
https://www.cancer.gov/about-cancer/treatment/research/car-t-cells

Causes of Death in Childhood Acute Lymphoblastic Leukemia at Hue Central Hospital for 10 Years (2008-2018) - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977218/#:~:text=Infection%20is%20the%20major%20cause,especially%20prevention%20and%20control%20infection.

Chimeric antigen receptor CAR Technique - Creative Biolabs (Updated Version) - YouTube
https://www.youtube.com/watch?v=hAbk7ggXzVg&t=315s&ab_channel=CreativeBiolabs

Costimulation in unmodified T cells and within chimeric antigen... | Download Scientific Diagram
https://www.researchgate.net/figure/Costimulation-in-unmodified-T-cells-and-within-chimeric-antigen-receptor-CAR-T-cells_fig1_333029514

Cytotoxic T cell - Wikipedia
https://en.wikipedia.org/wiki/Cytotoxic_T_cell