In this session we will go over the potential adverse outcomes of the Aspirin administration. These outcomes will be discussed for the following cells/tissues/organ systems:
Gastrointestinal tract.
Platelets
Renal system
Cardiovascular system
Nervous systems
Reproductive system
Hypersensitivity
Hematologic system
Hepatic system
Dermatologic system
Respiratory system
Skin
Other side-effects.

Objectives:
Discuss the side-effects of Aspirin and where applicable NSAIDs in general.
Discuss the mechanism of these side-effects on:
Gastrointestinal System
Stroke
Kidneys
Aspirin hypersensitivity
Aspirin and Reye Syndrome
Discuss Aspirin and NSAID interactions.
Discuss important drug-drug interactions involving Aspirin.
Discuss the clinical gems for Aspirin:
Aspirin resistance
Low-dose aspirin for preeclampsia
Aspirin and Ibuprofen
Aspirin for colorectal cancer prevention
Aspirin and Kawasaki disease
Aspirin hypersensitivity
Aspirin and kidneys
Aspirin use post GI bleed

Effects of aspirin on the gastrointestinal tract: Pros vs. cons - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400979/

Gastric Pits - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/gastric-pits

Does aspirin cause acute or chronic renal failure in experimental animals and in humans? - PubMed
https://pubmed.ncbi.nlm.nih.gov/8669425/#:~:text=Acute%20aspirin%20intoxication%20(%3E300%20mg,association%20with%20a%20pseudosepsis%20syndrome.

Hazardous Effect of Low-Dose Aspirin in Patients with Predialysis Advanced Chronic Kidney Disease Assessed by Machine Learning Method Feature Selection - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625790/

Aspirin | Circulation
https://www.ahajournals.org/doi/10.1161/01.cir.101.10.1206

Pain Medicines (Analgesics) | National Kidney Foundation
https://www.kidney.org/kidney-topics/pain-medicines-analgesics

Aspirin for Primary and Secondary Prevention of Mortality, Cardiovascular Disease, and Kidney Failure in the Chronic Renal Insufficiency Cohort (CRIC) Study - Kidney Medicine
https://www.kidneymedicinejournal.org/article/S2590-0595(22)00173-X/fulltext

Study Sheds Light on Aspirin’s Effects in Chronic Kidney Disease, but Questions Remain
https://consultqd.clevelandclinic.org/study-sheds-light-on-aspirins-effects-in-chronic-kidney-disease-but-questions-remain

Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493793/

Practical Guide on Aspirin Hypersensitivity: Key Points - American College of Cardiology
https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2024/05/08/19/22/aspirin-hypersensitivity-a-practical

Reye's Syndrome | National Institute of Neurological Disorders and Stroke
https://www.ninds.nih.gov/health-information/disorders/reyes-syndrome

Aspirin Resistance - PMC 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726079/ 
Low-Dose Aspirin Use for the Prevention of Preeclampsia and Related Morbidity and Mortality | ACOG 
https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2021/12/low-dose-aspirin-use-for-the-prevention-of-preeclampsia-and-related-morbidity-and-mortality 
Information about Taking Ibuprofen and Aspirin Together | FDA 
https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-about-taking-ibuprofen-and-aspirin-together 
Aspirin Use and Risk of Colorectal Cancer Among Older Adults | Cancer Screening, Prevention, Control | JAMA Oncology | JAMA Network 
https://jamanetwork.com/journals/jamaoncology/fullarticle/2775175 
Aspirin could help reduce colorectal cancer | News | Harvard T.H. Chan School of Public Health 
https://www.hsph.harvard.edu/news/hsph-in-the-news/aspirin-could-help-reduce-colorectal-cancer-in-high-risk-individuals/ 
Aspirin Use and Incidence of Colorectal Cancer According to Lifestyle Risk | Lifestyle Behaviors | JAMA Oncology | JAMA Network 
https://jamanetwork.com/journals/jamaoncology/article-abstract/2821928 
Kawasaki disease - Symptoms and causes - Mayo Clinic 
https://www.mayoclinic.org/diseases-conditions/kawasaki-disease/symptoms-causes/syc-20354598 
Aspirin Exacerbated Respiratory Disease (AERD) 
https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/aspirin-exacerbated-respiratory-disease-aerd 
Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial - The Lancet Diabetes & Endocrinology 
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(23)00327-3/abstract 
Aspirin for Primary Stroke Prevention; Evidence for a Differential Effect in Men and Women - PMC 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254866/ 
Resuming aspirin in patients with non-variceal upper gastrointestinal bleeding: a systematic review and meta-analysis - PMC 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079865/