Aspirin is a unique non-steroidal anti-inflammatory (NSAID) for many reasons. One reason is its irreversible inhibition of cyclooxygenase enzymes. Another is its effect on platelets and cardioprotective outcomes. Yet another interesting uniqueness of this drug is that it starts acting on platelets within minutes of absorbing in the portal circulation.
Objectives:
Classify aspirin within the broader context of NSAIDs and explain its unique characteristics.
Describe the primary mechanism of action of aspirin, including its effects on cyclooxygenase enzymes and platelet function.
Outline the ADME profile of aspirin, including its rapid absorption, distribution, and metabolism to salicylic acid.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK547742/
History of aspirin - Wikipedia
https://en.wikipedia.org/wiki/History_of_aspirin
The discovery of aspirin: a reappraisal - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1119266/#:~:text=Hoffmann%2C%20a%20chemist%20in%20the,acid%20on%2010%20August%201897.
Salicylic Acid (Aspirin) - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK519032/
Classify aspirin within the broader context of NSAIDs and explain its unique characteristics.
Describe the primary mechanism of action of aspirin, including its effects on cyclooxygenase enzymes and platelet function.
Outline the ADME profile of aspirin, including its rapid absorption, distribution, and metabolism to salicylic acid.
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1 Comments
peterjfw@*.com
Nov 23 2024, 7:06 pm
It is my understanding that inflammation and fever are both natural and beneficial reactions from the body, and should not be reduced. Unless in the case of fever it becomes very elevated. As for every degree of rise in temperature the immune system doubles its efficiency. Also I believe I heard you more or less mention this, Aspirin does make the blood less likely to clotting, but recent studies have shown it has little affect on clots in the Atrium. Those being the clots that are released during fibrillation, and are likely to cause strokes.