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Aspirin is a unique non-steroidal anti-inflammatory (NSAID) for many reasons. One reason is its irreversible inhibition of cyclooxygenase enzymes. Another is its effect on platelets and cardioprotective outcomes. Yet another interesting uniqueness of this drug is that it starts acting on platelets within minutes of absorbing in the portal circulation.
Objectives:
Classify aspirin within the broader context of NSAIDs and explain its unique characteristics.
Describe the primary mechanism of action of aspirin, including its effects on cyclooxygenase enzymes and platelet function.
Outline the ADME profile of aspirin, including its rapid absorption, distribution, and metabolism to salicylic acid.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK547742/
History of aspirin - Wikipedia
https://en.wikipedia.org/wiki/History_of_aspirin
The discovery of aspirin: a reappraisal - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1119266/#:~:text=Hoffmann%2C%20a%20chemist%20in%20the,acid%20on%2010%20August%201897.
Salicylic Acid (Aspirin) - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK519032/
Classify aspirin within the broader context of NSAIDs and explain its unique characteristics.
Describe the primary mechanism of action of aspirin, including its effects on cyclooxygenase enzymes and platelet function.
Outline the ADME profile of aspirin, including its rapid absorption, distribution, and metabolism to salicylic acid.
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MD., MSc., MSc., BSc
Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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