Ashwagandha is a herb used in Indian medicine (Ayurvedic medicine) for nearly 3000 years. It is found in India, Middle East, and Africa. It is reported to have anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, neuroprotective, adaptogenic, and reproductive and hormone-modulating effects. Let's review the anti-inflammatory aspects of this herb. We will discuss NF-kB pathway modulation.
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057#B41-pharmaceutics-15-01057
Ashwagandha - Special Subjects - Merck Manuals Consumer Version
https://www.merckmanuals.com/home/special-subjects/dietary-supplements-and-vitamins/ashwagandha
ASHWAGANDHA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha
Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines
https://www.spandidos-publications.com/ijmm/42/1/425
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00312-6
Frontiers | NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00705/full
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https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g002.jpg
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https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g001.jpg
Frontiers | What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?
https://www.frontiersin.org/articles/10.3389/fcell.2019.00154/full#:~:text=Nuclear%20factor%20kappa%20B%20(NF%2D%CE%BAB)%20is%20an%20ancient,cellular%20resistance%20to%20invading%20pathogens.
IκBα - Wikipedia
https://en.wikipedia.org/wiki/I%CE%BAB%CE%B1
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Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.
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2 Comments
iverjuster@*.com
Oct 04 2023, 2:31 pm
Thank you - a very enjoyable way to learn (especially compared to the way it's taught in med school). Question: If ashwagandha turns down the pathways that are designed to respond to pathogens, is it possible they make us LESS effective at fighting infections such as Covid? (Should we *in theory* advise patients with acute infection to stop taking ashwagandha until the acute phase is over ?)
canasena@*.com
Sep 09 2023, 12:18 pm
I am not sure how to edit my previous comment - I would like to add that I am also interested in Turmeric which is reported to be very effective for arthritic conditions.