Continuing with the series about the effects of Ashwagandha. Today we will discuss the anti-stress and adaptogenic effects of this herb. Ashwagandha helps improve neuronal plasticity, regeneration, and reduces damage and death of these cells. Ashwagandha triggers the upregulation of HSP70 proteins to accomplish this effect. Let's review.

Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057

Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular M...: Ingenta Connect
https://www.ingentaconnect.com/content/ben/ccp/2009/00000004/00000003/art00004

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895966/#:~:text=Heat%20shock%20protein%2070%20(Hsp70)%20is%20a%20molecular%20chaperone%20that,or%20aggregation%20until%20conditions%20improve.

Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0091305703001102

Phytotherapy Research | Medicinal Chemistry Journal | Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.858

Frontiers | c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
https://www.frontiersin.org/articles/10.3389/fphar.2015.00321/full

Frontiers | DAF-16/FOXO Transcription Factor in Aging and Longevity
https://www.frontiersin.org/articles/10.3389/fphar.2017.00548/full