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Angiotensin Converting Enzymes (ACE and ACE2)

Duration: 38:18

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palgreen57@*.com

Jun 12 2025, 3:07 am

Very detailed lecture. Thank you, Dr. Been.

In this foundational lecture, we will explore the contrasting roles of angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) in regulating inflammation and tissue homeostasis through the renin-angiotensin-aldosterone system (RAAS). We will analyze how ACE promotes proinflammatory effects via angiotensin II and its receptors, particularly AT1R, while ACE2 counters this activity through the generation of angiotensin-(1–7) and stimulation of MAS receptors. Emphasis will be placed on the downstream effects of receptor activation and the clinical relevance of this balance. This mechanistic understanding will prepare us for the following session on pharmacological agents—ACE inhibitors and ARBs—and their therapeutic implications in hypertension, cardiovascular disease, and inflammation.

Learning Objectives:

Differentiate between the enzymatic functions of ACE and ACE2 in the RAAS pathway.
Identify the primary receptor targets of angiotensin II and angiotensin-(1–7), including AT1R, AT2R, and MAS receptor.
Explain how activation of these receptors leads to either proinflammatory or anti-inflammatory outcomes.
Illustrate the molecular and physiological consequences of the ACE/ACE2 axis imbalance in disease states.

Differentiate between the enzymatic functions of ACE and ACE2 in the RAAS pathway.
Identify the primary receptor targets of angiotensin II and angiotensin-(1–7), including AT1R, AT2R, and MAS receptor.
Explain how activation of these receptors leads to either proinflammatory or anti-inflammatory outcomes.
Illustrate the molecular and physiological consequences of the ACE/ACE2 axis imbalance in disease states.

Following answers are created by ChatGPT. Occasionally the answer may be harmful, incorrect, false, misleading, incomplete, or limited in knowledge of world. Please contact your doctor for all healthcare decisions. Also, double check the answer provided by the AI below.

Faculty

In addition to the presenter, following authors may have helped with the content writing, review, or approval:

Dr. Mobeen Syed

CME, CE, CEU and Other Credit Types:

ACCME Accreditation Statement
The DrBeen Corp is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA Credit Designation Statement
The DrBeen Corp designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Information

In accordance with the disclosure policies of DrBeen Corp and the ACCME (Accreditation Council for Continuing Medical Education), we are committed to upholding principles of balance, independence, objectivity, and scientific rigor in all of our Continuing Medical Education (CME) and Continuing Education (CE) activities. These policies include the careful management and mitigation of any relevant financial relationships with organizations that are not eligible.
All members of the Activity Planning Committee and presenters have disclosed their relevant financial relationships. The DrBeen Corp CE Committee has thoroughly reviewed these disclosures and determined that these relationships are not deemed inappropriate in the context of their respective presentations. Additionally, they are found to be consistent with the educational objectives and the integrity of the activity.

Faculty	Disclosures
Dr. Mobeen Syed	Author declares no conflict of interest.

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Instructors

Dr. Mobeen Syed

MD., MSc., MSc., BSc

Mobeen Syed is the CEO of DrBeen Corp, a modern online medical education marketplace. Mobeen is a medical doctor and a software engineer. He graduated from the prestigious King Edward Medical University Lahore. He has been teaching medicine since 1994. Mobeen is also a software engineer and engineering leader. In this role, Mobeen has run teams consisting of hundreds of engineers and millions of dollars of budgets. Mobeen loves music, teaching, and doing business. He lives in Cupertino CA.

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