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Animal studies have demonstrated the neuroprotective role of methylene blue especially when administered within an hour of transient ischemic insult of the neurons. Methylene blue is antioxidant, anti-inflammatory, and induces autophagy while reducing apoptosis. Let's review its mechanisms.
Contraindications: https://www.rxlist.com/consumer_provayblue_methylene_blue/drugs-condition.htm
The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core | PLOS ONE https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131929
AMPK - Legere Pharmaceuticals https://www.legerepharm.com/ampk/
Schematic illustration of the mTOR signaling pathway. AMPK indicates... | Download Scientific Diagram https://www.researchgate.net/figure/Schematic-illustration-of-the-mTOR-signaling-pathway-AMPK-indicates-AMP-activated_fig1_228089413
Model of the AMPK and mTOR signaling network in mammalian cells. AMPK... | Download Scientific Diagram https://www.researchgate.net/figure/Model-of-the-AMPK-and-mTOR-signaling-network-in-mammalian-cells-AMPK-inhibits-mTOR_fig1_221865491
Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light https://www.frontiersin.org/articles/10.3389/fncel.2015.00179/full
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation | Translational Neurodegeneration | Full Text https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00197-z
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2 Comments
michael@*.com
Apr 19 2023, 5:27 pm
I use a powdered form of USP grade MB from cztl.bz (no connection with them). You can create whatever concentration you need, typical: 0.1% (w/v) up to 2.0% (w/v).
lkrzs@*.com
Mar 19 2023, 7:12 pm
What happened to the youtube videos?