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Alzheimer's Disease Review

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What is the role of Astrocyte in AD?

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[Errata: In the early part of the video, I wrote recurrent function instead of recurrent infections. Please keep this in mind while studying.]

*It is an insidious, progressive, degenerative disease of the neurons.
*Alzheimer's incidence is increasing in the developed nations.
*Alzheimer's disease is one of the most costly disease to manage. Continuous care is needed, recurrent infections, and dehydration are common.

Dr. Mobeen presents the pathophysiology of Alzheimer's disease. Following topics are discussed:
Anterolateral amnesia. (Loss of forming new memories.)
Speech disorders.
Mood imbalance.
Disruption of the executive functions of the brain. (Difficulty with decision making.)
Initiates at the Hippocampus.

Genes involved:
1-14 - Senilin
11 - SDLR1
21 - APP
19 - ApoE4

Alzheimer's can be early onset or late onset. Genes 19 and 21 are involved in the early onset Alzheimer's.

*Tau protein's role.
*Beta amyloid's pathologies. (A-Beta lipoprotein.)
*Role of alpha, beta, and gamma secretase.
*Formation of senile plaques due to the beta and gamma secretase action instead of alpha and beta secretase.
*Immune system activation due to the senile plaque formation.
*Destruction of the brain tissue due to the inflammatory reaction due to the senile plaques.
*Clogging of the neural synapses by the senile plaque proteins.
*Loss of cytoskeletal integrity due to the disruption of the Tau proteins.
*Disruption of the nutrients flow from the neuronal cell body to the axonal terminal.
*Formation of the Tau aggregates.
*ApoE-4 gene's role is discussed.
*Widening of the sulci and gyri as a result of the degeneration is presented.
*Role of increased load of the APP protein or the gene up regulation forming APP.



Dr. Mobeen Syed

Mobeen Syed M.D, MS Graduated from King Edward Medical University. Entrepreneur, Medical Educator, CEO and founder of Drbeen corp.

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