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Microbiology - Neisseria Gonorrhea (UW 3320)
Mobeen Syed, MD - 2018-09-14 17:24:15

Clinical presentation of disseminated gonococcal infection (not presented in FA or MMRS)

Purulent arthritis without skin lesions

OR

Triad of:
Tenosynovitis (eg, wrist, ankles, fingers & knees)

Dermatitis (pustules, maculas, papules & bullae)
Migratory asymmetric polyarthralgia without purulent arthritis

Microbiology - Neisseria Gonorrhea (UW 3320)
Mobeen Syed, MD - 2018-09-17 18:25:07

UW 2239. Gonococcus and Chlymidia are the two most common causes of sexually transmitted epidedymitis (usually in young.)

 

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Microbiology - Neisseria Gonorrhea (UW 3320)
Mobeen Syed, MD - 2018-09-14 17:39:34

In the UW 4488 they say that with the gonococcal infection there can be a risk of HIV, Syphilis, Hepatitis B, and Chlymidial co-infections.

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Microbiology - Neisseria Gonorrhea (UW 3320)
Mobeen Syed, MD - 2018-09-14 17:31:23

Blood cultures can frequently be negative. Use nucleic acid amplification testing. (This is also true for chlamydia, however, in gonococci blood culture can be positive.)

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Microbiology - Neisseria Gonorrhea (UW 3320)
Mobeen Syed, MD - 2018-09-14 17:27:21

Treatment

IV ceftriaxone 1 g/day for 7-14 days, switch to PO (cefixime) when clinically improved

Joint drainage for purulent arthritis
Empiric azithromycin (single 1-g dose) OR doxycycline for 7 days for concomitant chlamydia! infection

Treat sexual partner

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Microbiology - Neisseria Gonorrhea (UW 3320)
Mobeen Syed, MD - 2018-09-14 17:26:14

Diagnosis

Blood cultures (2 sets) but may be negative
Synovial fluid analysis may show up to 50,000 cells/mm3 Urethral, cervical, pharyngeal or rectal cultures Recommend HIV & syphilis screen
Recurrent DGI: check terminal complement activity

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