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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 11:51:36
S. Pyogenes is PYR +, so are enterococci.
PYR + test is used for the rapid presumptive identification of streptococci.
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 13:16:10
Tx for S. toxic shock syndrome: Penicillin G + Clindamycin (shuts down ribosomal actions -> stops synthesis of pyrogenic toxin and M protein.)
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 13:14:31
Tx for necrotizing fascitis: Penicllin G + Clindamycin (to shutdown streptococcal metabolism.)
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 13:13:25
Tx for the skin infections: penicillinase resistant penicillin -> Dicloxacillin (also covers staphylococcus)
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 12:29:52
Streptococcal deoxyribonucleases -> break DNA -> increases viscosity of the purulant exudates.
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 12:26:51
Streptokinase -> transforms plaminogen to plasmin -> active proteolytic -> breaks down fibrin and other proteins -> breaks blood clots -> helps S. Pyogenes to escape from the blood clots. (Streptokinase is used for pulmonary emboli, coronary artery and venous thrombosis.)
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 12:20:48
Pyrogenic/antigenic exotoxin -> Streptococcal pyrogenic exotoxin -> Spe. 3 types. SpeA most studied -> superantigen -> binds to MHC II (V beta region) on T cells -> massive release of cytokines -> TSS + Scarlet Fever.
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 12:14:03
Enzymes: Streptokinase, deoxyribonuclease, hyaluronidase, pyrogenic (erythrogenic) exotoxin, Hemolysins (streptolysin O and S)
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 12:03:26
Cell wall has C Carb (Group A), M protein -> prevents complement activation and phagocytosis, however, B cells make antibodies against it -> opsonization -> phagocytosis.
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 11:58:15
G+, (Erysipelas, throat, skin, fasica, scarlet fever, toxic shock, heart, kidneys). PYR+, M proteins -> Rh fever, ASO titer, anti-DNAse B antibodies, JONES criteria, scarlet fever -> circumoral pallor.
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Microbiology - FA 133 Streptococcus Pyogenes
Mobeen Syed, MD - 2018-09-07 11:51:52
https://catalog.hardydiagnostics.com/cp_prod/content/hugo/PYRTestKit_Rgnt.htm
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